Modafinil chemical name is 2‑[(diphenylmethyl)sulfinyl]acetamide and was approved by the FDA in 1998 for the treatment of narcolepsy and other sleep disorders. Apart from treating sleep apnea and shift work disorder, Modafinil's has recently shown the capacity to improve cognitive activity.
Studies show that Modafinil's activity on alleviating depression, psychosis, and role in controlling emotions. Analysis in the United Kingdom indicates that better grades on Modafinil is achievable and has attracted high use.
1. Promotion of Alertness and Wakefulness
The drug was initially designed to promote alertness, wakefulness, and mental function in a patient with excessive sleep. Modafinil indicates control over the circadian cycle with the reduction of excessive sleep in the daytime. Additionally, it has minimal effects on nighttime sleep and the Rapid Eye Movement (REM) sleep, thus used for sleep disorders. Impressively, the drug demonstrates the capability of restoring learning abilities for amphetamine and cocaine addicts.
Modafinil boosts alertness in individuals and mental functions for sustained periods.
Effects experienced by individuals using Modafinil indicate an increase in the execution of tasks, attention, and learning. In 1997, a study stated that Modafinil was more effective than amphetamines on blocking sleep drive and enhancing motor activity. The drug increases the concentration and activity of neuromodulators and transmitters.
2. Cognitive enhancement
Studies on Modafinil's cognitive function's effects are positive for both healthy and patients with brain disorders and diseases. Modafinil has shown increased motor functions, faster response times, memory, attention, and learning for all individuals. However, these cognitive effects of Modafinil are marked in individuals with low-performance. Additionally, Modafinil enhances verbal fluency, subjects focus, motivation, and memory.
Mood elevation results in boosting motivation and focus on patients. Modafinil can elevate the mental function in cognitive conditions such as psychosis, depression, and Attention Deficit Hyperactivity Disorder (ADHD). These conditions can stem from drug dependence, neurologic, or physical disorder resulting in attention processing impairment.
3. Planning and Performance
Studies carried out between 1990 and 2014 recorded and discussed the benefits comprehensively on the cognitive function of Modafinil. The studies delineated benefits on planning, decision-making, learning, creativity, and flexibility vouching for using Modafinil for productivity.
Additionally, Modafinil increases performance markedly in the complex task and those that take longer. The effects are pronounced in decision-making and planning rather than flexibility and memory.
4. Emitted depression
Recent studies of the effects of Modafinil on memory in an individual with depression are promising and positive. Moreover, researchers found that Modafinil can improve working memory performance, and episodic memory precipitated in remitted depression.
The improvement in episodic memory is linked to neurochemical changes in the brain's hippocampal regions through glutamate hormone. Additionally, it increases blood flow to areas of the brain with glutamate receptors such as the hippocampus.
5. First Episode Psychosis
Modafinil indicated an increase in the working memory for psychotic and schizophrenia patients. The drug recorded a reduction in search errors and enhanced strategy use. Modafinil showed synergy between its administrations after previous cognitive exposure to a specific task. The working memory for people who carry out a particular job for the second time while on Modafinil medication is increased.
Furthermore, this improvement stems from dopaminergic neuronal modulation by Modafinil. The drug is suspected of recruiting dopamine in specific brain areas involved in the processing and maintenance of memory. Many studies carried out on the effects of Modafinil indicate little or no side effects. Therefore, these studies promote the notion by university students for better grades on Modafinil.
6. Overall Cognitive Benefits
Modafinil's research indicates its effectiveness in promoting brain health. The medication reduces the effect of free radicals that damage brain tissue. Doctors, therefore, prescribe Modafinil as an antioxidant to protect neuronal membranes in the brain. Modafinil controls impulsive behavior such as those seen in alcoholism, schizophrenia, and gambling addicts.
7. Postulated Mechanism of Action
Although Modafinil's mechanism is unknown, its effects on various neuromodulators inform on a possible mechanism. The mechanism of action is unique and slightly similar to other nootropics. The effects focus majorly on the amygdala and hypothalamus regions, particularly specific neurons. Hormones affected by Modafinil include the orexin system, dopamine, serotonin, histamine, and norepinephrine.
Narcolepsy is caused by a lack or low levels of orexin in the hypothalamus involved in the circadian cycle and appetite. Modafinil for productivity during sleep and neurologic disorder achieves arousal and wakefulness via stimulating these regions to produce histamine. Histamine, furthermore, imparts alertness in individuals. Improved alertness under Modafinil occurs via increasing norepinephrine postulated as a blockade of norepinephrine transporter.
Modafinil does not act directly on dopamine receptors to increase the neurotransmitter levels in the brain. Dopamine is associated with reward response controls impulse seen addiction cases. Cognitive ability stems from Modafinil's effect on increasing the concentration of glutamate and GABA. Additionally, Modafinil increases serotonin levels in the brain by imparting on its release, thereby controlling moods.
Modafinil is available to buy online at a fraction of the cost of Provigil. However, you should have a prescription beforehand. Always consult your doctor before ordering Modafinil online.
Free e-Book: 101 Nootropic
Discover the 7 important facts about nootropics for a complete beginner.