Centrophenoxine Review – Its Effects, Dosage, Benefits, Risks & More

If you have been looking for a way to boost your memory and general cognitive function, Centrophenoxine is an excellent nootropic supplement that can help you do just that.  

Centrophenoxine was first created to treat Alzheimer's disease, the inadequate flow of blood to the brain as well as cognitive decline related to age. Brilliant scientists working at the French National Scientific Research Centre produced this outstanding compound way back in 1959! 

Originally developed in France, this compound is a combination of two chemicals found in both natural food sources like fish and seafood, as well as within the brain itself. 

One of the chemicals which makes up Centrophenoxine is referred to as Dimethyl-aminoethanol (DMAE). It is also made up of Parachlorphenoxyacetic acid (pCPA), referred to as auxins, which is a synthetic version of plant growth hormones. 

It is available in a supplement form and has incredible benefits. For a very brief overview to help you quickly understand what Centrophenoxine is including some of its amazing benefits, check out this video here.

1. Learning And Recollection Ability May Be Improved

Deemed a nootropic, Centrophenoxine is claimed to improve certain aspects of cognitive function, more specifically, memory and learning.

According to some studies, older people benefit more from Centrophenoxine as opposed to their younger counterparts. However, no studies exist to support the use of Centrophenoxine in young adults.

A study involving healthy elderly adults showed that Centrophenoxine assisted in improving their formation of long term memories and enhancing mental alertness.

A study conducted with a total of 50 elderly patients with dementia were shown to have improved their memory with the use of Centrophenoxine.

2. Can Be Helpful With Fighting The Signs Of Aging And Offers Protection Against Neurological Issues

Lipofuscin, an age pigment, collects in neurons and other cells, but Centrophenoxine reduces this accumulation. The accumulation of lipofuscin is linked to age-related disorders, including Alzheimer's disease. 

The brain is protected from age-related decline due to Centrophenoxine acting as an antioxidant and fighting off free radicals. Toxins are flushed out, and damaged cells are also repaired.

3. Can Be Helpful In Uplifting Moods

Users have reported that their moods improved, and motivation increased with Centrophenoxine supplementation.

Centrophenoxine was also reported to reduce anxiety in animal studies conducted.

No human research has been conducted to conclude on the potential mood benefits related to Centrophenoxine. An early study has suggested that DMAE improved energy levels and the wellbeing of the subjects involved in the study. Thus, Centrophenoxine’s DMAE component may help to improve moods.

Even though more human studies would need to be conducted to make sure the same results are consistent amongst humans, the incredible anxiety-reducing benefits found to be experienced in rats are confirmed.

The Worrying Factors

The incredible benefits of Centrophenoxine have been brought to light. However, we need to understand any ill effects which may be experienced when taking this supplement.

Centrophenoxine is able to increase the levels of acetylcholine which in turn causes the following mild side effects:

• Nausea
• Headaches
• Gut Issues
• Sleeplessness

You Should Avoid Centrophenoxine if you…

• Suffer from major depression, Parkinson’s disease, seizures, bipolar disorders. The acetylcholine levels may negatively affect individuals with all of these conditions, as reported in scientific research, and its best to steer clear of Centrophenoxine in this case. 
• Are pregnant as the DMAE component of Centrophenoxine reportedly might cause birth defects.
• Have not consulted with a doctor or certified health professional.
• Are using any other supplements, medications, or drugs.

Centrophenoxine's main component DMAE, may somewhat increase acetylcholine levels. Interactions with other drugs could negatively affect this neurotransmitter, including acetylcholine esterase (AChE) inhibitors, cholinergic drugs, and anticholinergic drugs. 

There is a lack of research to demonstrate potential interactions of Centrophenoxine with these substances. It is therefore strongly suggested to use caution if you want to take Centrophenoxine together with other drugs.

As Centrophenoxine is considerably new, evidence regarding how safe it is for human users’ needs to be collected, along with how often negative side effects can occur. 

Experimenting with this compound should, therefore, be avoided.

How Centrophenoxine Works In the Body

A synthetic version of DMAE (dimethylaminoethanol), which forms part of Centrophenoxine has been altered to increase absorption and its ability to cross the blood-brain barrier. Centrophenoxine also includes PCPA (para-chlorphenoxyacetic).

Centrophenoxine is metabolized within your body's liver as a fat-soluble compound. However, all the specific mechanisms are not currently clearly understood as it is still the subject of research from years that have passed and continues to be researched.

Acetylcholine Levels Increase In The body

Acetylcholine levels are increased in the synaptic vesicles as soon as Centrophenoxine spans into the blood-brain barrier. 

Acetylcholine levels are increased through conversion into an intermediary phospholipid used to create acetylcholine. Or, Acetylcholine levels are increased by Centrophenoxine being broken down into choline and then converts to acetylcholine.

Acetylcholine is a neurotransmitter most prevalently linked with memory and general cognitive function. The fact that Centrophenoxine is able to increase acetylcholine levels is its primary way in which it behaves as a nootropic.  

Oxygen And Glucose Availability To The Brain Increases

Centrophenoxine improves cognition in many other ways, which include increasing oxygen and glucose availability to the brain as well as reducing concentrations of cellular waste and toxins negatively impacting cognition.

Anti-aging and nootropic properties are indicative of Centrophenoxine, which is also an antioxidant effective in ridding the cells of toxins and facilitating repair caused by toxin damage. 

Concentrations of waste produced by lipid peroxidation or oxidative degradation of fats in the cell membranes are also reduced as a result of Centrophenoxine.

Lipid peroxidation is responsible for cellular damage and is also linked to aging. It is also associated with various diseases and disorders, which include neurological dysfunction, cardiac arrest, and cancer.

Waste Accumulation Is Reduced

Potassium accumulation is linked to age-related cognitive reduction. However, Centrophenoxine is considered to end and reverse this accumulation.  

Aging cells contain accumulated waste material, lipofuscin. Centrophenoxine demonstrates the ability to reduce as well as eliminate the accumulation of lipofuscin, which is generally found in liver, kidney, heart muscle, and retina cells. 

Lipofuscin is also found in nerve and ganglion cells. Centrophenoxine's ability to eliminate and reduce the accumulation of lipofuscin is invaluable as lipofuscin is linked to various age-related disorders.

Recommended Dosage

Suggested dosages for Centrophenoxine range between daily doses of 250mg and 3000 mg split into two. This dose is deemed safe for most adults who are considered healthy.

You should especially consult with a medical professional if you want to exceed this dose in order to maximize the potential anti-aging benefits. For anti-aging effects, you would have to increase the dose significantly. However, care should be taken, and the advice of a health professional should be sought for your own safety. 

As with all supplements, start off slowly, at a low but effective dose, with gradual increments as required.

It is advisable to administer Centrophenoxine with food as it is fat-soluble.

Final Words

Centrophenoxine is an effective nootropic supplement that can be safely taken when consulting health professionals, especially if you are taking other medications. 

Centrophenoxine significantly benefits users by considerably enhancing memory, ability to learn as well as focus and intelligence. It also acts as an anti-aging supplement.

Despite limited research, Centrophenoxine has a great track record. It is an affordable supplement you may want to consider if you are looking to boost your cognitive function and reverse aging!